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妊娠相关嗜酸性肉芽肿性多血管炎发作:病例报告及文献复习

Flare of eosinophilic granulomatosis with polyangiitis related to pregnancy: Case report and review of the literature.

作者信息

Matsuno Osamu, Minamoto Seijiro

机构信息

Department of Medicine for Allergic Disease, Osaka Habikino Medical Center, 3-7-1 Habikino, Habikino City, Osaka, 583-8588, Japan.

出版信息

Respir Med Case Rep. 2018 Nov 4;26:23-26. doi: 10.1016/j.rmcr.2018.10.027. eCollection 2019.

Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by excessive eosinophil accumulation in the peripheral blood and affected tissues with development of granulomatous vasculitic organ damage. It is strongly associated with asthma and ear-nose-throat disease. It often affects patients between the ages of 40 and 60 years. It is unknown whether pregnancy impacts the disease activity of EGPA, including initial diagnosis or relapse. Because of its rarity and age of susceptibility, there are few reported cases describing pregnancy in women with quiescent or active EGPA. Here, we describe a young woman who experienced EGPA relapse during pregnancy and subsequently underwent an elective caesarean section for non-reassuring fetal status at 37 weeks without complication.

摘要

嗜酸性肉芽肿性多血管炎(EGPA)的特征是外周血和受累组织中嗜酸性粒细胞过度积聚,并伴有肉芽肿性血管炎性器官损伤。它与哮喘和耳鼻喉疾病密切相关。它常影响40至60岁的患者。目前尚不清楚妊娠是否会影响EGPA的疾病活动,包括初始诊断或复发。由于其罕见性和易感年龄,很少有报道描述静止期或活动期EGPA女性的妊娠情况。在此,我们描述一名年轻女性,她在怀孕期间经历了EGPA复发,随后在37周时因胎儿状况不佳接受了择期剖宫产,且未出现并发症。

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