Khoor A, Fleming M V, Purcell C A, Seidman J D, Ashton A H, Weaver D L
Department of Pathology, Vanderbilt University Medical Center, Nashville, Tenn, USA.
Arch Pathol Lab Med. 1995 Sep;119(9):848-50.
Teratomas of the uterus are very rare, and a uterine teratoma with pulmonary differentiation has not, to our knowledge, been described previously. In this article, we report such a case in a 33-year-old woman, who presented with heavy vaginal bleeding and a polypoid mass of the uterine cervix. The cervical lesion was composed entirely of mature lung tissue, including bronchial, bronchiolar, and alveolar structures. The presence of well-differentiated respiratory epithelial cells, ie, Clara cells and alveolar type II cells, is confirmed by immunohistochemistry. The patient had no history of dilatation and curettage; therefore, implantation of fetal tissue could be excluded from the differential diagnoses. Since this is a newly developed mass in an adult individual, we favor a neoplastic process over heterotopia and interpret the lesion as unilateral lung development in an extragonadal mature teratoma.
子宫畸胎瘤非常罕见，据我们所知，此前尚未有关于具有肺分化的子宫畸胎瘤的描述。在本文中，我们报告了一名33岁女性的此类病例，该患者出现大量阴道出血及宫颈息肉样肿物。宫颈病变完全由成熟肺组织构成，包括支气管、细支气管和肺泡结构。免疫组化证实存在分化良好的呼吸道上皮细胞，即克拉拉细胞和II型肺泡细胞。该患者无刮宫史；因此，鉴别诊断中可排除胎儿组织植入。鉴于这是一名成年个体新出现的肿物，我们认为这是一个肿瘤性病变而非异位，将该病变解释为性腺外成熟畸胎瘤中的单侧肺发育。
