Vittorio F, Ronsisvalle G, Marrazzo A, Blandino G
Istituto di Chimica Farmaceutica e Tossicologica, Università di Catania, Italy.
Farmaco. 1995 Apr;50(4):265-72.
2-Methyl-1-oxo-1,2-dihydro-3-carbazoyl-4-phenylisoquinoline 2, 1-methoxy-7 and 1-chloro-3-carbazoyl-4-phenylisoquinoline 12 as well as a series of their 2-hydrazono-derivatives 3 a-i, 8 a-i and 14 a-i were synthesized and evaluated for their antibacterial and antifungal activities, in vitro. Compound 3 h was fairly active against Staphylococcus aureus, Staphylococcus epidermidis and streptococci group B.
合成了2-甲基-1-氧代-1,2-二氢-3-咔唑基-4-苯基异喹啉2、1-甲氧基-7和1-氯-3-咔唑基-4-苯基异喹啉12以及它们的一系列2-腙衍生物3a-i、8a-i和14a-i，并对其体外抗菌和抗真菌活性进行了评估。化合物3h对金黄色葡萄球菌、表皮葡萄球菌和B组链球菌具有相当的活性。
