Vittorio F, Pappalardo M S, Ronsisvalle G, Blandino G
Istituto di Chimica Farmaceutica e Tossicologica, Universita' di Catania, Italy.
Farmaco Sci. 1988 Mar;43(3):239-50.
2,4-Dimethyl-1-oxo-1,2-dihydro-3-carbazoyl-isoquinoline (II), 1-chloro-, 1-methoxy-3-carbazoyl-4-methylisoquinoline (VI, X) and a series of their hydrazonic derivatives have been synthesized and tested in vitro for antibacterial and antifungal activities. 1-(1-Chloro-4-methyl-3-isoquinolinoyl)-2-(5-nitro-2-furfurylide ne) hydrazine (VII h) proved to be the most effective in the series (MIC 0.78 micrograms/ml) and was more potent than furazolidone against several strains of S.aureus; the same compound also showed a moderate antifungal activity.
已合成了2,4-二甲基-1-氧代-1,2-二氢-3-咔唑基异喹啉（II）、1-氯-、1-甲氧基-3-咔唑基-4-甲基异喹啉（VI、X）及其一系列腙衍生物，并对其进行了体外抗菌和抗真菌活性测试。1-(1-氯-4-甲基-3-异喹啉甲酰基)-2-(5-硝基-2-糠叉基)肼（VII h）在该系列中被证明是最有效的（最低抑菌浓度为0.78微克/毫升），并且对几种金黄色葡萄球菌菌株的效力比呋喃唑酮更强；该化合物还表现出中等程度的抗真菌活性。
