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5-HT1A and D-2 receptor affinity of o-methoxyphenylpiperazine derivatives with terminal benzamide fragment on N-4 alkyl chain. 2.

作者信息

Perrone R, Berardi F, Leopoldo M, Tortorella V, Lograno M D, Daniele E, Govoni S

机构信息

Dipartimento Farmaco-Chimico, Bari, Italy. off

出版信息

Farmaco. 1995 Jul-Aug;50(7-8):505-10.

PMID:7669188
Abstract

The synthesis of some o-methoxyphenylpiperazines with a benzamide moiety on N-4 alkyl chain was accomplished and their affinity for dopamine and serotonin receptor subtypes was assayed by in vitro receptor binding. The results show that several derivatives had a good affinity both on D-2 and 5-HT1A receptors, the IC50s ranging from 10(-7) to 10(-8) M.

摘要

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