Kalef-Ezra J, Challa A, Chaliasos N, Hatzikonstantinou I, Papaefstathiou I, Cholevas V, Glaros D, Lapatsanis P
Department of Medical Physics, Medical School, University of Ioannina, Greece.
Bone. 1995 Jun;16(6):651-5. doi: 10.1016/8756-3282(95)00117-v.
Homozygous beta-thalassemia is a severe hereditary disorder associated with osteopenia. Recently it was suggested that thalassemia minor may be a risk factor for osteoporosis. The purpose of the present study was to investigate this suggestion. Bone mineral status was assessed in 22 premenopausal women and 21 men with beta-thalassemia minor. In vivo neutron activation analysis was applied to measure hand-bone phosphorus (HBP), single-photon absorptiometry to measure forearm bone mineral content (BMC), and dual-energy X-ray absorptiometry to measure spinal bone mineral density (BMD). Comparison of the HBP, BMC, and BMD values with those of sex- and age-matched healthy subjects without the beta-thalassemia trait failed to indicate a statistically significant difference for either sex group. Concerning the biochemical markers of bone metabolism that were studied (serum calcium, phosphate, alkaline phosphatase, osteocalcin, and parathyroid hormone, and 3-h fasting urine calcium-to-urine creatinine ratio) no difference was observed between the study subjects and matched controls. In conclusion, the present study showed that subjects with beta-thalassemia minor are not at risk for osteoporosis.
纯合子β地中海贫血是一种与骨质减少相关的严重遗传性疾病。最近有研究表明，轻度地中海贫血可能是骨质疏松症的一个危险因素。本研究的目的是对这一观点进行调查。对22名绝经前患有轻度β地中海贫血的女性和21名男性的骨矿物质状况进行了评估。采用体内中子活化分析法测量手部骨骼磷含量（HBP），用单光子吸收法测量前臂骨矿物质含量（BMC），并用双能X线吸收法测量脊柱骨矿物质密度（BMD）。将HBP、BMC和BMD值与无β地中海贫血特征的性别和年龄匹配的健康受试者进行比较，结果表明，两组性别在统计学上均无显著差异。在所研究的骨代谢生化标志物（血清钙、磷、碱性磷酸酶、骨钙素、甲状旁腺激素以及3小时空腹尿钙与尿肌酐比值）方面，研究对象与匹配的对照组之间未观察到差异。总之，本研究表明，轻度β地中海贫血患者不存在骨质疏松症风险。
