Krishnan S, Sturtridge W C, Olivieri N F, Collins A F, Qureshi R Y, Krishnan M, Belluzzo N, Bogdanovich E, Lui S M
Medical Physics Laboratory, Toronto Hospital, Ontario, Canada.
Biol Trace Elem Res. 1994 Fall;43-45:309-14. doi: 10.1007/BF02917329.
In this study, 50 thalassemia patients were tested using dual-energy X-ray absorptiometry (DEXA) and in vivo neutron activation analysis (IVNAA) to determine their bone mineral status. Both techniques were suitable for this purpose. Lower age was found to correspond to lower liver iron content and higher bone mineral content in the normal range. Patients undergoing treatment with transfusion had higher bone mineral content. Osteopenic patients had higher hepatic iron content than those with normal bone status. In the case of DEXA, bone mineral content (BMC) divided by height cubed was found to be a better indicator of bone mineral status than the BMD usually given. Liver density as determined by DEXA correlates well with hepatic iron.
在本研究中，使用双能X线吸收法（DEXA）和体内中子活化分析（IVNAA）对50例地中海贫血患者进行检测，以确定其骨矿物质状况。两种技术均适用于此目的。研究发现，年龄越小，肝脏铁含量越低，骨矿物质含量在正常范围内越高。接受输血治疗的患者骨矿物质含量较高。骨质减少患者的肝脏铁含量高于骨状态正常的患者。就DEXA而言，发现骨矿物质含量（BMC）除以身高的立方比通常给出的骨密度（BMD）是更好的骨矿物质状况指标。通过DEXA测定的肝脏密度与肝脏铁含量密切相关。
