Olsen K S, Svendsen L B, Larsen F S, Paulson O B
Department of Anaesthesia, Rigshospitalet, Copenhagen, Denmark.
Br J Anaesth. 1995 Jul;75(1):51-4. doi: 10.1093/bja/75.1.51.
We have studied the effects of labetalol on cerebral blood flow (CBF) and cerebral oxygen metabolism (CMRO2) in eight healthy volunteers. CBF was measured by single photon emission computerized tomography before and during infusion of labetalol. CMRO2 was calculated as CBF x cerebral arteriovenous oxygen content difference (CaO2-CvO2). CBF autoregulation was tested during infusion of labetalol by changing arterial pressure and estimating relative changes in global CBF from changes in (CaO2-CvO2). CBF before and during infusion of labetalol was 67 and 65 ml/100 g min-1, respectively (P > 0.05). CMRO2 was 2.9 and 2.8 ml/100 g min-1, respectively (P > 0.05). CBF autoregulation was preserved in all subjects. The lower limit of CBF autoregulation was 88 mm Hg (94% of baseline mean arterial pressure). We conclude that labetalol did not influence global or regional CBF, or CMRO2, and CBF autoregulation was preserved.
我们研究了拉贝洛尔对8名健康志愿者脑血流量（CBF）和脑氧代谢（CMRO2）的影响。在输注拉贝洛尔之前和期间，通过单光子发射计算机断层扫描测量CBF。CMRO2通过CBF×脑动静脉氧含量差（CaO2 - CvO2）计算得出。在输注拉贝洛尔期间，通过改变动脉压并根据（CaO2 - CvO2）的变化估计全脑CBF的相对变化来测试CBF自动调节功能。输注拉贝洛尔之前和期间的CBF分别为67和65 ml/100 g·min-1（P>0.05）。CMRO2分别为2.9和2.8 ml/100 g·min-1（P>0.05）。所有受试者的CBF自动调节功能均得以保留。CBF自动调节的下限为88 mmHg（基线平均动脉压的94%）。我们得出结论，拉贝洛尔不影响全脑或局部CBF或CMRO2，并且CBF自动调节功能得以保留。
