Bac P, Pages N, Herrenknecht C, Teste J F
Laboratoire de Pharmacologie, Faculté de Pharmacie, Châtenay-Malabry, France.
Magnes Res. 1995 Mar;8(1):37-45.
Magnesium deprivation induced interspecific aggressive behaviour (muricidal behaviour) in rats undoubtedly attributable to magnesium deficiency since magnesium chloride, by correcting magnesium deficiency, suppressed it. Inhibition of magnesium deficiency-induced behaviour by various magnesium salts should enable the classification of the therapeutic effects of these salts. Consequently we compared the effects of various magnesium salts used therapeutically on the inhibition of the acute muricidal behaviour induced by magnesium deficiency. All the magnesium salts used (chloride, pidolate, aspartate, gluconate, lactate) suppressed the muricidal behaviour. There was no significant difference in the duration of the treatment needed to inhibit this comportment for each of the salts studied. In contrast, significant differences appeared, concerning the different phases of muricidal behaviour. Magnesium pidolate significantly increased the attack latency (P < 0.05). By repeating the muricidal assays, we showed that magnesium pidolate treated rats had a muricidal behaviour rate which was lower than that of the other magnesium salt-treated rat groups. Consequently, it can be assumed that all the magnesium salts used had an acute anti-muricidal, perhaps anti-stress, effect and that magnesium pidolate presented, on this experimental model the greatest efficacy.
镁缺乏诱发大鼠种间攻击行为（杀鼠行为），这无疑归因于镁缺乏，因为氯化镁通过纠正镁缺乏而抑制了这种行为。各种镁盐对镁缺乏诱发行为的抑制作用应能对这些盐的治疗效果进行分类。因此，我们比较了治疗中使用的各种镁盐对抑制镁缺乏诱发的急性杀鼠行为的效果。所有使用的镁盐（氯化物、匹多酸盐、天冬氨酸盐、葡萄糖酸盐、乳酸盐）均抑制了杀鼠行为。对于所研究的每种盐，抑制这种行为所需的治疗持续时间没有显著差异。相比之下，在杀鼠行为的不同阶段出现了显著差异。匹多酸镁显著延长了攻击潜伏期（P < 0.05）。通过重复杀鼠试验，我们发现用匹多酸镁处理的大鼠的杀鼠行为发生率低于其他用镁盐处理的大鼠组。因此，可以假设所有使用的镁盐都具有急性抗杀鼠作用，可能还有抗应激作用，并且在这个实验模型上，匹多酸镁表现出最大的疗效。
