Spasov A A, Iezhitsa I N, Kharitonova M V, Kravchenko M S
Institute of Pharmacology, Department of Pharmacology, Volgograd State Medical University.
Bull Exp Biol Med. 2007 Aug;144(2):214-6. doi: 10.1007/s10517-007-0292-7.
We studied the effect of Mg-L-aspartate, MgCL2, and their combinations with vitamin B6, magneB6, and MgSO4 on seizure threshold in rats with dietary Mg2+ deficiency. Mg2+ deficiency was followed by a decrease in the threshold dose of corazol (from 79.20 to 49.48 mg/kg), shortening of the latency of the first jerk (by 33.6%, p=0.012), and reduction of the time to the first episode of clonic seizures (by 32.6%, p=0.011). Seizure threshold and latencies of the first jerk and first episode of clonic seizures increased over 3 weeks after peroral administration of Mg2+ salts. The combination of Mg2+ salts and pyridoxine was most effective in this respect.
我们研究了L-天冬氨酸镁、氯化镁及其与维生素B6的组合（镁B6）以及硫酸镁对饮食中镁离子缺乏的大鼠癫痫阈值的影响。镁离子缺乏后，戊四氮的阈剂量降低（从79.20降至49.48毫克/千克），首次抽搐的潜伏期缩短（缩短33.6%，p = 0.012），首次阵挛性癫痫发作的时间缩短（缩短32.6%，p = 0.011）。口服镁盐3周后，癫痫阈值以及首次抽搐和首次阵挛性癫痫发作的潜伏期增加。在这方面，镁盐和吡哆醇的组合最为有效。
