Hanna C L, McKinna F E, Williams L B, Morrey D, Adams M, Mason M D, Maughan T S
Velindre Hospital, Cardiff, UK.
Br J Cancer. 1995 Sep;72(3):774-6. doi: 10.1038/bjc.1995.409.
We have conducted a retrospective study of high-dose folinic acid and 5-fluorouracil in 96 patients with advanced colorectal cancer. Patients received 200 mg m-2 (maximum 300-350 mg) folinic acid by infusion over 2 h followed by an i.v. bolus of 5-fluorouracil 400 mg m-2 then an infusion of 5-fluorouracil 600 mg m-2 over 22 h. This was repeated over the next 24 h. The schedule was given every 2 weeks for four cycles; thereafter patients with objective response continued to a maximum of eight cycles. The overall response rate was 10.6% in 85 evaluable patients. The median duration of response was 11 months. The median survival was 6 months. Toxicity was low, only one patient experiencing toxicity greater than WHO grade II (grade IV platelet toxicity). Diarrhoea, nausea, vomiting and mucositis also occurred but were mild and infrequent. Our low response rate may be related to factors such as patient characteristics or duration of treatment.
我们对96例晚期结直肠癌患者进行了大剂量亚叶酸钙和5-氟尿嘧啶的回顾性研究。患者先静脉输注200mg/m²（最大剂量300 - 350mg）亚叶酸钙，持续2小时，随后静脉推注400mg/m²的5-氟尿嘧啶，然后在22小时内静脉输注600mg/m²的5-氟尿嘧啶。在接下来的24小时内重复此过程。该方案每2周进行一次，共四个周期；此后，有客观缓解的患者最多持续进行八个周期。85例可评估患者的总缓解率为10.6%。缓解的中位持续时间为11个月。中位生存期为6个月。毒性较低，只有1例患者出现大于世界卫生组织二级的毒性（四级血小板毒性）。腹泻、恶心、呕吐和黏膜炎也有发生，但程度较轻且不常见。我们较低的缓解率可能与患者特征或治疗持续时间等因素有关。
