Bober L A, Kranepool M J, Hollander V P
Cancer Res. 1976 Mar;36(3):927-9.
Small amounts (0.1 ng to 5.0 mug) of Escherichia coli endotoxin protect normal female BALB/c mice against challenge with low doses of syngeneic mineral oil-induced 315 plasma cell tumor. Significant protection was most evident when mice were treated with endotoxin 11 days and 5 days before inoculation with 50 to 100 tumor cells i.p., and endotoxin treatment continued twice a week for the entire experiment. Tumors induced by 10,000 cells s.c. were similarly affected by this treatment. The antitumor action of endotoxin was obliterated when higher challenges of tumor cells or solid tumor pieces were used. Omission of endotoxin pretreatment resulted in a loss of the effect against i.p.-induced tumors but not against s.c.-induced tumor.
小剂量（0.1纳克至5.0微克）的大肠杆菌内毒素可保护正常雌性BALB/c小鼠免受低剂量同基因矿物油诱导的315浆细胞瘤的攻击。当小鼠在腹腔注射50至100个肿瘤细胞前11天和5天用内毒素处理，并在整个实验过程中每周两次持续进行内毒素处理时，显著的保护作用最为明显。皮下注射10000个细胞诱导的肿瘤也受到这种处理的类似影响。当使用更高剂量的肿瘤细胞或实体瘤块进行攻击时，内毒素的抗肿瘤作用消失。省略内毒素预处理会导致对腹腔注射诱导的肿瘤的作用丧失，但对皮下注射诱导的肿瘤则不然。
