Nagase H, Bryson S, Cordell H, Kemp C J, Fee F, Balmain A
CRC Beatson Laboratories, Department of Medical Oncology, University of Glasgow, UK.
Nat Genet. 1995 Aug;10(4):424-9. doi: 10.1038/ng0895-424.
Genetic susceptibility to chemically induced skin cancer in mice is controlled by multiple unlinked genetic loci. Mus spretus mice have dominant resistance genes which confer resistance to interspecific F1 hybrids with susceptible Mus musculus strains. We have mapped three major resistance loci using a combination of Mapmaker/QTL analysis and multiple regression analysis to mouse chromosomes 5 and 7. At least two independent loci on chromosome 7 exert their effects primarily during benign tumour development and have very little influence on tumour progression. On the other hand, probably a single locus on chromosome 5 affects both early and late stages of malignancy. The results indicate that benign and malignant tumours are largely under independent genetic control.
小鼠对化学诱导皮肤癌的遗传易感性由多个不连锁的基因位点控制。家鼠（Mus spretus）具有显性抗性基因，可赋予其对与易感小家鼠（Mus musculus）品系的种间F1杂种的抗性。我们使用Mapmaker/QTL分析和多元回归分析相结合的方法，将三个主要抗性位点定位到小鼠的5号和7号染色体上。7号染色体上至少有两个独立的位点，其作用主要在良性肿瘤发展过程中发挥，对肿瘤进展的影响很小。另一方面，5号染色体上可能只有一个位点影响恶性肿瘤的早期和晚期阶段。结果表明，良性和恶性肿瘤在很大程度上受独立的遗传控制。
