Klimes I, Vrána A, Kunes J, Seböková E, Dobesová Z, Stolba P, Zicha J
Diabetes and Nutrition Research Laboratory, Slovak Academy of Sciences, Bratislava.
Blood Press. 1995 May;4(3):137-42. doi: 10.3109/08037059509077585.
Hereditary hypertriglyceridemic rats (hHTg) were developed as a new genetic model for the study of relationships between blood pressure (BP) and metabolic abnormalities. This strain has been produced by selective inbreeding from Wistar rats according to the rise of plasma triglycerides induced by a high-sucrose diet. Though hHTg rats display hypertriglyceridemia, impaired glucose tolerance, hyperinsulinemia, insulin resistance and increased BP even without nutritional stimuli, high sucrose feeding further aggravates these symptoms. High plasma triglycerides levels in hHTg rats seem to be a consequence of their hyperproduction. Impaired insulin action is responsible for the defective glucoregulation in this strain. The loss of insulin responsiveness might be due to a reduction in the number of glucose transporters. Highly significant relationships among plasma triglycerides, ouabain-resistant Na+ transport and BP were demonstrated in the hHTg rats. Segregating populations (F2 hybrids) should be used for genetic analysis of the primary role of lipid and/or ion transport abnormalities in the pathogenesis of this form of genetic hypertension.
遗传性高甘油三酯血症大鼠（hHTg）作为一种新的遗传模型，用于研究血压（BP）与代谢异常之间的关系。该品系是通过对Wistar大鼠进行选择性近亲繁殖培育而成，依据高蔗糖饮食诱导的血浆甘油三酯升高情况选育。尽管hHTg大鼠即便在无营养刺激时也表现出高甘油三酯血症、糖耐量受损、高胰岛素血症、胰岛素抵抗及血压升高，但高蔗糖喂养会进一步加重这些症状。hHTg大鼠血浆甘油三酯水平升高似乎是其过度生成的结果。胰岛素作用受损是该品系糖调节缺陷的原因。胰岛素反应性丧失可能是由于葡萄糖转运体数量减少所致。在hHTg大鼠中，血浆甘油三酯、哇巴因抵抗性Na +转运与血压之间存在高度显著的相关性。应使用分离群体（F2杂种）对脂质和/或离子转运异常在这种遗传性高血压发病机制中的主要作用进行遗传分析。
