代谢综合征的大鼠模型
Rat Models of Metabolic Syndrome.
作者信息
Kwitek Anne E
机构信息
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.
出版信息
Methods Mol Biol. 2019;2018:269-285. doi: 10.1007/978-1-4939-9581-3_13.
Abstract
Metabolic syndrome is a complex disorder that comprises several other complex disorders, including obesity, hypertension, dyslipidemia, and diabetes. There are several rat models that encompass component features of MetS. Some models are inbred strains selected for one or more traits underlying MetS; others are population models with genetic risk for MetS traits, are induced by environmental stressors such as diet, are spontaneous monogenic mutant models, or are congenic strains derived from a combination of these models. Together they can be studied to identify the genetic and physiological underpinnings of MetS to identify candidate genes or mechanisms for study in human MetS subjects.
摘要
代谢综合征是一种复杂的病症，它包含其他几种复杂病症，包括肥胖症、高血压、血脂异常和糖尿病。有几种大鼠模型涵盖了代谢综合征的组成特征。一些模型是为代谢综合征潜在的一种或多种特征而选择的近交系；其他的是具有代谢综合征特征遗传风险的群体模型，由饮食等环境应激源诱发，是自发单基因突变模型，或是源自这些模型组合的同类系。通过对它们进行共同研究，可以确定代谢综合征的遗传和生理基础，以识别在人类代谢综合征患者中进行研究的候选基因或机制。
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2
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3
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4
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5
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