Rho J Y, Hobatho M C, Ashman R B
Department of Biomedical Engineering, University of Memphis, TN 38152, USA.
Med Eng Phys. 1995 Jul;17(5):347-55. doi: 10.1016/1350-4533(95)97314-f.
Mechanical properties of cortical and cancellous bone from eight human subjects were determined using an ultrasonic transmission technique. Raw computerized tomography (CT) values obtained from scans of the bones in water were corrected to Hounsfield units. The correlations between CT numbers and mechanical property estimated from cortical bone were found to be low (r2 < 0.2), while these relationships for cancellous bone were found to be higher (r2 > 0.6). These results suggest that CT values may be useful in predicting mechanical properties only for cancellous bone. Poor correlations were found between modulus in the radial or circumferential direction and modulus in the superior-inferior direction for cortical bone, whereas good correlations were found between modulus in the anterior-posterior direction or medial-lateral direction and modulus in the S-I direction for cancellous bone. These results indicate that modulus in the radial or circumferential direction could not be predicted from modulus in the S-I direction for cortical bone, but could be predicted for cancellous bone. The predictive capabilities of linear and power models evaluated for cancellous bone alone were approximately equal. However, the power function gives a better fit of data at the low and high density values. The specific relationships, depending on the types of bone, that predict elastic modulus from density and CT numbers were suggested for human cortical and cancellous bone. These specific correlations may help a number of researchers develop more accurate models; however, these hypotheses should be proven by further study.
采用超声透射技术测定了8名人类受试者皮质骨和松质骨的力学性能。从水中骨骼扫描获得的原始计算机断层扫描（CT）值被校正为亨氏单位。结果发现，皮质骨的CT值与力学性能之间的相关性较低（r2 < 0.2），而松质骨的这些关系则较高（r2 > 0.6）。这些结果表明，CT值可能仅对松质骨的力学性能预测有用。皮质骨在径向或周向的模量与上下方向的模量之间相关性较差，而松质骨在前后方向或内外方向的模量与上下方向的模量之间相关性良好。这些结果表明，皮质骨在径向或周向的模量不能从上下方向的模量预测，但松质骨可以。仅针对松质骨评估的线性和幂函数模型的预测能力大致相当。然而，幂函数在低密度和高密度值时对数据的拟合更好。针对人类皮质骨和松质骨，提出了根据密度和CT值预测弹性模量的具体关系，具体取决于骨的类型。这些特定的相关性可能有助于许多研究人员开发更准确的模型；然而，这些假设应通过进一步研究来验证。
