Ogra Y, Suzuki K T
Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Res Commun Mol Pathol Pharmacol. 1995 May;88(2):196-204.
Tetrathiomolybdate (TTM) removes copper (Cu) accumulating in a form bound to metallothionein (MT) in the liver of LEC rats (Long-Evans rats with a cinnamon-like coat color). The first step in the removal of Cu from Cu-MT has been shown to form a complex between MT and TTM through (MT)-S-Cu-S-(TTM) bridges (referred to as MT/TTM complex). Additional TTM was demonstrated to remove Cu from MT/TTM complex as the second step to form Cu/TTM complex by liberating MT. The Cu/TTM complex binds specifically to albumin in serum and to high molecular weight proteins in the absence of albumin, and is assumed to be a form of Cu for efflux by the treatment with TTM.
四硫代钼酸盐（TTM）可去除在LEC大鼠（毛色呈肉桂色的Long-Evans大鼠）肝脏中以与金属硫蛋白（MT）结合的形式积累的铜（Cu）。从铜-金属硫蛋白中去除铜的第一步已被证明是通过（MT）-S-Cu-S-（TTM）桥在MT和TTM之间形成复合物（称为MT/TTM复合物）。额外的TTM被证明作为第二步从MT/TTM复合物中去除铜，通过释放MT形成铜/TTM复合物。铜/TTM复合物在血清中与白蛋白特异性结合，在没有白蛋白的情况下与高分子量蛋白质结合，并被认为是通过TTM处理进行外排的一种铜的形式。
