Kojima T, Doi K, Kishi M, Horiguchi Y
Department of Pharmacology and Toxicology, Kanagawa Prefectural Public Health Laboratories, Japan.
Res Commun Mol Pathol Pharmacol. 1995 May;88(2):233-6.
Plasma total plasmin activity in spontaneously hypertensive rats (SHR) was lower than in normal Wistar rats, and in male SHR, plasmin activity was higher than that in females. However, this sex-related difference in SHR was less than that observed in our previous study in normal Wistar rats. Furthermore, we and others have reported higher levels of coagulant functions in male than in female rats. These studies were taken to indicate that there is a greater necessity for higher fibrinolytic activity in males than in females. The results of the present study suggest that hypertension is a risk factor of thrombosis in view of the increased fibrinolytic activity, and in SHR there is also a sex-related difference in plasma total plasmin activity.
自发性高血压大鼠（SHR）的血浆总纤溶酶活性低于正常Wistar大鼠，并且在雄性SHR中，纤溶酶活性高于雌性。然而，SHR中这种与性别相关的差异小于我们之前在正常Wistar大鼠研究中观察到的差异。此外，我们和其他人报道雄性大鼠的凝血功能水平高于雌性。这些研究表明，雄性比雌性更需要更高的纤溶活性。本研究结果表明，鉴于纤溶活性增加，高血压是血栓形成的一个危险因素，并且在SHR中血浆总纤溶酶活性也存在与性别相关的差异。
