Battistella P A, Carollo C, Pellegrino P A, Soriani S, Scarpa P
Department of Pediatrics, University of Padua, Italy.
Childs Nerv Syst. 1995 Jun;11(6):329-34. doi: 10.1007/BF00301664.
Spontaneous occlusion of the circle of Willis, i.e., moyamoya disease (MMD), is a clinical disease entity angiographically characterized by progressive and bilateral stenosis of the carotid bifurcation, with a hazy collateral network at the base or convexity of the brain. Although the importance of computed tomography (CT) and conventional magnetic resonance (MR) imaging in diagnosing MMD has already been determined, conventional arteriography is still regarded as necessary for definitive diagnosis. Magnetic resonance angiography (MR-A) is a very recent vascular imaging technique which allows noninvasive and direct imaging of vessels without the use of contrast medium. We present four pediatric cases of MMD, evaluated by conventional angiography, CT, MR imaging, and MR-A. Our data demonstrate that MR-A is successful both in allowing detection of occlusive disease of the basal portion of the internal carotid artery and large branch basal cerebral vessels and demonstrating the collateral vessels at the base of the brain. As a noninvasive procedure, MR-A promises to become a valuable alternative to classical angiography in the diagnosis of MMD.
大脑 Willis 环自发性闭塞，即烟雾病（MMD），是一种临床疾病实体，血管造影表现为双侧颈内动脉分叉处进行性狭窄，脑底部或凸面有模糊的侧支循环网络。尽管计算机断层扫描（CT）和传统磁共振（MR）成像在诊断烟雾病中的重要性已得到确定，但传统血管造影仍被认为是明确诊断所必需的。磁共振血管造影（MR - A）是一种非常新的血管成像技术，可在不使用造影剂的情况下对血管进行无创直接成像。我们展示了 4 例烟雾病儿科病例，通过传统血管造影、CT、MR 成像和 MR - A 进行评估。我们的数据表明，MR - A 不仅成功检测到颈内动脉基部和大脑基底大分支血管的闭塞性疾病，还能显示脑底部的侧支血管。作为一种无创检查方法，MR - A 有望成为烟雾病诊断中传统血管造影的有价值替代方法。
