Brdicka R
Ustav hematologie a krevní transfuze, Praha.
Cas Lek Cesk. 1995 Jun 28;134(13):418-21.
The chromosome number 13 which has been investigated least so far is known above all due to two loci: WND-responsible for Wilson's disease caused by impaired copper metabolism and RB1 which as to its effects belongs among so-called anti-oncogenes, i.e. suppressors of oncogenic processes. A special section of the paper deals with DNA - repair systems and their hereditary disorders.
迄今为止研究最少的13号染色体首先因两个基因座而为人所知:WND,它与铜代谢受损导致的威尔逊氏病有关;以及RB1,就其作用而言,它属于所谓的抑癌基因,即致癌过程的抑制因子。本文的一个特别章节讨论了DNA修复系统及其遗传性疾病。