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心脏外科手术和介入手术后感染性心内膜炎的风险。

The risk of infective endocarditis after cardiac surgical and interventional procedures.

作者信息

de Gevigney G, Pop C, Delahaye J P

机构信息

Hôpital Cardiovasculaire et Pneumologique, BP Lyon Montchat, France.

出版信息

Eur Heart J. 1995 Apr;16 Suppl B:7-14. doi: 10.1093/eurheartj/16.suppl_b.7.

Abstract

The risk of infective endocarditis after cardiac surgery relates mainly to the risk of infective endocarditis on prosthetic valves. The frequency of prosthetic infective endocarditis varies according to the criteria used in the literature, ranging from 0.4 to 1.3% for early infective endocarditis, with an annual linear risk of late infective endocarditis of 0.5%. This figure seems to be independent of either the type or the location of prostheses, but it does nevertheless increase if more than one valve has been replaced. The most commonly isolated microorganisms in early infective endocarditis are staphylococci. The bacteriological findings in late prosthetic infective endocarditis are similar to those seen in the native disease. The portal of entry is more easily identified in early than in late infective endocarditis (50%). The risk of infective endocarditis in surgically treated congenital heart disease is very low when the patient has a left-to-right shunt or valvar stenosis; it increases amongst patients with tetralogy of Fallot and patients with complex cyanotic congenital heart disease, mainly when there is a residual ventricular septal defect or prior palliative surgery. The risk of infective endocarditis in patients with intracavitary electrodes such as pacemakers and defibrillators, after the interventional procedure itself and after heart transplant, is very low. This leads us to conclude that antibiotic prophylaxis is only warranted in those patients with a prosthetic valve and after surgical treatment of tetralogy of Fallot and other complex cyanotic congenital heart diseases.

摘要

心脏手术后感染性心内膜炎的风险主要与人工瓣膜感染性心内膜炎的风险相关。人工瓣膜感染性心内膜炎的发生率根据文献中使用的标准而有所不同,早期感染性心内膜炎的发生率为0.4%至1.3%,晚期感染性心内膜炎的年线性风险为0.5%。这个数字似乎与人工瓣膜的类型或位置无关,但如果置换了多个瓣膜,感染性心内膜炎的风险确实会增加。早期感染性心内膜炎中最常分离出的微生物是葡萄球菌。晚期人工瓣膜感染性心内膜炎的细菌学发现与原发性疾病相似。早期感染性心内膜炎比晚期更容易确定感染入口(50%)。对于患有左向右分流或瓣膜狭窄的患者,手术治疗先天性心脏病后感染性心内膜炎的风险非常低;法洛四联症患者和复杂的青紫型先天性心脏病患者的感染风险增加,主要是在存在残余室间隔缺损或先前进行姑息性手术的情况下。对于植入了腔内电极(如起搏器和除颤器)的患者,在介入操作本身之后以及心脏移植之后,感染性心内膜炎的风险非常低。由此我们得出结论,仅在那些植入人工瓣膜的患者以及法洛四联症和其他复杂的青紫型先天性心脏病手术治疗后才需要进行抗生素预防。

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