Segal S
Division of Biochemical Development and Molecular Diseases, Children's Hospital of Philadelphia, PA 19104, USA.
Eur J Pediatr. 1995;154(7 Suppl 2):S82-6. doi: 10.1007/BF02143810.
To assess in utero effects of galactose, diets containing large amounts of the sugar have been fed to pregnant rats with examination of the fetuses and newborns. Galactose levels in fetal blood parallel those of the dam and amniotic fluid contains high concentrations of galactose and galactitol. In the offspring and in the fetuses cataracts, and a decrease in brain weight, protein content and DNA are observed. There is an elevated content of galactitol and decrease in myo-inositol in the brain of galactose-intoxicated newborns. Brain synaptosomes of young rats whose mothers were fed galactose show a reduced response in vitro to acetylcholine as evidenced by a decrease in incorporation of myo-inositol into phosphatidylinositol and an inappropriate change in phosphatidylinositol content. The data indicate that there can be significant effects in the offspring of pregnant rats fed a high galactose diet. The findings support the concept that in utero toxicity may occur in the human galactosemic fetus.
为了评估半乳糖在子宫内的影响，已给怀孕大鼠喂食大量含该糖的饮食，并对胎儿和新生儿进行检查。胎儿血液中的半乳糖水平与母鼠平行，羊水含有高浓度的半乳糖和半乳糖醇。在后代和胎儿中，观察到白内障，脑重量、蛋白质含量和DNA减少。半乳糖中毒新生儿的大脑中半乳糖醇含量升高，肌醇含量降低。母亲喂食半乳糖的幼鼠的脑突触体在体外对乙酰胆碱的反应降低，这表现为肌醇掺入磷脂酰肌醇减少以及磷脂酰肌醇含量发生不适当变化。数据表明，喂食高半乳糖饮食的怀孕大鼠的后代可能会有显著影响。这些发现支持了人类半乳糖血症胎儿可能发生子宫内毒性的概念。
