Boire D, Morris R, Ptito M, Lepore F, Frost D O
Département de Psychologie Université de Montréal, Québec, Canada.
Exp Brain Res. 1995;104(2):275-86. doi: 10.1007/BF00242013.
During normal postnatal development, there is an overproduction and subsequent partial elimination of the callosal projections of cortical areas 17 and 18 in the cat. In the present study, we investigated how neonatal splitting of the optic chiasm affects this process. Our results indicate that neonatal splitting of the optic chiasm exaggerates the normally occurring partial elimination of immature callosal projections: it causes a significant reduction in the total number of neurons in the supragranular layers that send an axon through the corpus callosum. It does not, however, cause a significant change in the number of callosally projecting neurons in the infragranular layers. These data suggest that in addition to other factors previously described, the level or spatial distribution of correlated binocular input to visual cortical neurons may influence the stabilization/elimination of immature callosal connections.
在正常的出生后发育过程中，猫的17区和18区皮质的胼胝体投射会过度产生，随后部分消除。在本研究中，我们调查了新生期视交叉分裂如何影响这一过程。我们的结果表明，新生期视交叉分裂会加剧正常情况下未成熟胼胝体投射的部分消除：它会导致通过胼胝体发出轴突的颗粒上层神经元总数显著减少。然而，它不会导致颗粒下层中胼胝体投射神经元的数量发生显著变化。这些数据表明，除了先前描述的其他因素外，视觉皮质神经元相关双眼输入的水平或空间分布可能会影响未成熟胼胝体连接的稳定/消除。
