[Base pair substitutions induced by Escherichia coli K-12 mutator gene prv].

Using the trpA system of Yanofsky, it is shown that the mutator gene prv of Escherichia coli K-12 induces transitions in both directions (A:T in equilibrium G:C), and not A:T leads to leads to C:G and C:G leads to A:T transversions. The prv1 mutation was found to be recessive in prv+/prv1 merodiploid.