Dolci G, Ripari M, Pacifici L, Umile A
Odontoiatric Clinic, La Sapienza University, Rome, Italy.
Int J Clin Pharmacol Res. 1994;14(5-6):185-91.
Two hundred ninety-eight patients with post-operative pain after the surgical removal of an impacted third molar were randomly assigned, on a double-blind basis, to receive a single oral dose of piroxicam 20 mg, or piroxicam-beta-cyclodextrin equivalent to 20 mg piroxicam, or paracetamol 500 mg, or placebo. Using a semi-quantitative self-rating scale, patients rated their pain and its relief at 30-min intervals for the first 2 h, and then hourly for 4 h after treatment administration. All active medications were reported to be significantly superior to placebo. The three active drugs were comparable for the degree of analgesia up to the third hour, after which the effect of paracetamol decreased significantly as compared to piroxicam-beta-cyclodextrin and piroxicam. Piroxicam-beta-cyclodextrin and paracetamol were more rapid than piroxicam in inducing analgesia. The tolerability for the active drugs was comparable to that for placebo.
298例拔除阻生第三磨牙后出现术后疼痛的患者被随机双盲分组，分别口服单剂量20毫克吡罗昔康、相当于20毫克吡罗昔康的吡罗昔康-β-环糊精、500毫克对乙酰氨基酚或安慰剂。患者使用半定量自评量表，在治疗给药后的前2小时每隔30分钟对疼痛及其缓解情况进行评分，之后4小时每小时评分一次。据报告，所有活性药物均显著优于安慰剂。在第三个小时之前，三种活性药物的镇痛程度相当，之后与吡罗昔康-β-环糊精和吡罗昔康相比，对乙酰氨基酚的效果显著下降。吡罗昔康-β-环糊精和对乙酰氨基酚诱导镇痛的速度比吡罗昔康更快。活性药物的耐受性与安慰剂相当。
