Tsai S C, Kao C H, Pan D Y, ChangLai S P, Wang S J
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan, Republic of China.
Gaoxiong Yi Xue Ke Xue Za Zhi. 1995 Aug;11(8):430-5.
Fifteen patients with non-insulin dependent diabetes mellitus (NIDDM) were included in the study. Esophageal motility, including esophageal mean transit time (MTT), residual fraction (RF), and retrograde index (RI), was evaluated and calculated by the radionuclide esophageal transit test (RETT). The baseline study was performed before the oral erythromycin therapy. After a 2-week course treatment, the subjects underwent a second study. The results showed that (A) in the baseline study, 93% (14/15) of NIDDM patients had a longer MTT, 67% (10/15) had a higher RF and 80% (12/15) had a higher RI; and (B) after treatment with erythromycin, 73% (11/15) of the patients had a shorter MTT and a lower RF, and 60% (9/15) of the patients had a lower RI. We conclude that (1) most of the NIDDM patients had esophageal motility disorders and (2) a 2-week oral erythromycin therapy can improve diabetic esophagoparesis, as evaluated by non-invasive REET.
本研究纳入了15例非胰岛素依赖型糖尿病（NIDDM）患者。通过放射性核素食管通过试验（RETT）评估并计算食管动力，包括食管平均通过时间（MTT）、残留分数（RF）和逆行指数（RI）。在口服红霉素治疗前进行基线研究。经过2周疗程的治疗后，受试者接受第二次研究。结果显示：（A）在基线研究中，93%（14/15）的NIDDM患者MTT延长，67%（10/15）的患者RF升高，80%（12/15）的患者RI升高；（B）红霉素治疗后，73%（11/15）的患者MTT缩短、RF降低，60%（9/15）的患者RI降低。我们得出结论：（1）大多数NIDDM患者存在食管动力障碍；（2）为期2周的口服红霉素治疗可改善糖尿病性食管轻瘫，这通过非侵入性REET评估得出。
