静脉注射红霉素对健康受试者食管动力的影响。
The effect of intravenous erythromycin on esophageal motility in healthy subjects.
作者信息
Tzovaras G, Xynos E, Chrysos E, Mantides A, Vassilakis J S
机构信息
Department of General Surgery, University Hospital of Heraklion, Medical School, University of Crete, Heraklion, Greece.
出版信息
Am J Surg. 1996 Mar;171(3):316-9. doi: 10.1016/S0002-9610(97)89633-X.
BACKGROUND
It has been confirmed that erythromycin has gastrokinetic properties of enhancing gastric emptying both in health and disease. The objective of the present study was to investigate any possible effect of erythromycin on esophageal motility.
METHODS
In 14 healthy subjects, standard esophageal manometry was performed before and after the intravenous administration of 200 mg of erythromycin. The calculated manometric parameters of esophageal motility were the lower esophageal sphincter (LES) pressure; the amplitude and duration of peristalsis at 5, 10, and 15 cm proximal to the LES; and the velocity and strength of peristalsis at 5 cm proximal to the LES.
RESULTS
Erythromycin significantly increased the LES pressure (P<0.001), and the amplitude (P=0.002), duration (P=0.003), strength (P=0.014) and velocity (P=0.008) of peristalsis at 5 cm proximal to LES. Erythromycin also increased the amplitude of peristalsis at 10 cm proximal to the LES (P=0.035).
CONCLUSION
Erythromycin affects the motility of the distal esophagus.
背景
已证实红霉素在健康和疾病状态下均具有增强胃排空的胃肠动力特性。本研究的目的是调查红霉素对食管动力的任何可能影响。
方法
对14名健康受试者在静脉注射200mg红霉素前后进行标准食管测压。计算得出的食管动力测压参数包括食管下括约肌（LES）压力；LES近端5cm、10cm和15cm处蠕动的幅度和持续时间；以及LES近端5cm处蠕动的速度和强度。
结果
红霉素显著增加了LES压力（P<0.001），以及LES近端5cm处蠕动的幅度（P=0.002）、持续时间（P=0.003）、强度（P=0.014）和速度（P=0.008）。红霉素还增加了LES近端10cm处蠕动的幅度（P=0.035）。
结论
红霉素影响食管远端的动力。
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