Ishikawa N, Takeda T, Wu J, Echigo J, Itai Y
Institute of Clinical Medicine, University of Tsukuba.
Kaku Igaku. 1995 Jul;32(7):659-65.
Early scintigraphy, that obtained 6 hours after intravenous administration of a low dose of 123I-metaiodobenzylguanidine (111 MBq) was evaluated for diagnostic efficacy. The accumulation of 123I-MIBG in the tumor masses of nine patients with pheochromocytoma and one patient with cortical adenoma were noted. The smallest pheochromocytoma visualized was 3 cm in diameter. The hepatic uptake of this radiolabeled compound was helpful to understand the anatomical position of the abnormal uptake. Three of five postoperative cases of pheochromocytoma showed uptake in the metastasis in the skeleton or recurrences in the neck or contralateral adrenal gland. No ectopic pheochromocytoma was found in the pelvic cavity. Faint accumulation in the normal medulla was noted in 45% of the cases. The present results demonstrate that superior images can be obtained in scintigrams takes 6 hours after administration of a lower dose of 123I-MIBG.
对静脉注射低剂量（111MBq）的123I-间碘苄胍6小时后获得的早期闪烁扫描图像的诊断效能进行了评估。记录了9例嗜铬细胞瘤患者和1例皮质腺瘤患者肿瘤块中123I-MIBG的摄取情况。可视化的最小嗜铬细胞瘤直径为3厘米。这种放射性标记化合物在肝脏的摄取有助于了解异常摄取的解剖位置。5例嗜铬细胞瘤术后病例中有3例在骨骼转移灶、颈部或对侧肾上腺复发处显示摄取。盆腔未发现异位嗜铬细胞瘤。45%的病例在正常髓质中观察到轻微积聚。目前的结果表明，给予较低剂量的123I-MIBG后6小时进行闪烁扫描可获得优质图像。
