Caballero O, Ferris J, Escobedo J M, Pérez A
Med Clin (Barc). 1989 Apr 15;92(14):526-9.
At times pheochromocytoma raises diagnostic problems which cannot be solved by methods already incorporated into diagnostic evaluation, such as catecholamine measurement, echography and computed tomography. These drawbacks are more common with small size tumors, malignant extra-adrenal pheochromocytoma and some cases of relapse after surgery. The present study reports the results of 123I-meta-iodobenzylguanidine (MIBG) scintiscan in 30 patients with suspected pheochromocytoma. The head, the thorax and the abdomen were scanned in all patients after 3, 24 and 48 hours. Areas of normal and abnormal uptake were evaluated in these areas. The scintiscan was positive in seven cases with a diagnosis of pheochromocytoma, which showed markedly increased uptake persisting throughout the study. The results of other studies are analyzed and the functional character of MIBG, its sensitivity and specificity, and the advantages of 123I over 131I are discussed.
有时，嗜铬细胞瘤会引发一些诊断难题，而诸如儿茶酚胺测定、超声检查和计算机断层扫描等已纳入诊断评估的方法无法解决这些问题。这些缺点在小尺寸肿瘤、恶性肾上腺外嗜铬细胞瘤以及某些术后复发病例中更为常见。本研究报告了对30例疑似嗜铬细胞瘤患者进行的123I-间碘苄胍（MIBG）闪烁扫描的结果。所有患者在3小时、24小时和48小时后对头、胸和腹部进行扫描。对这些区域的正常和异常摄取区域进行评估。闪烁扫描在7例诊断为嗜铬细胞瘤的病例中呈阳性，这些病例在整个研究过程中显示摄取明显增加且持续存在。分析了其他研究的结果，并讨论了MIBG的功能特性、其敏感性和特异性以及123I相对于131I的优势。
