Regensteiner J G, Sippel J, McFarling E T, Wolfel E E, Hiatt W R
Department of Medicine, University of Colorado School of Medicine, Denver 80262, USA.
Med Sci Sports Exerc. 1995 May;27(5):661-7.
Persons with non-insulin-dependent diabetes mellitus (NIDDM), in the absence of complications, have a decreased exercise performance compared with nondiabetic subjects. However, degree of impairment and factors associated with reduced exercise performance have not been fully characterized. Maximal exercise performance using a graded treadmill protocol was assessed in 10 sedentary persons with uncomplicated NIDDM (aged 51 +/- 7) and 10 healthy age- and activity-matched controls. Potential correlates of exercise performance measured included fasting and post-exercise glucose concentrations and fasting insulin concentration, hemoglobin A1C, hematocrit, and whole blood viscosity. At maximal exercise, diabetic persons had a 24% lower maximal walking time and 20% lower maximal VO2 than controls (both P < 0.05), while hemodynamic measures did not differ between groups. During graded exercise, at work loads below the maximal one, the relationship between VO2 and work load was significantly lower in persons with NIDDM than controls by an average of 16%. No correlations were found between peak exercise performance and any of the potential correlates of exercise performance measured. We conclude that persons with NIDDM have an impaired peak exercise performance not associated with degree of glycemic control. The reduced rate of increase in oxygen consumption during increasing submaximal work loads in NIDDM suggests that limitations in oxygen delivery may impair exercise performance in otherwise healthy persons with diabetes.
无并发症的非胰岛素依赖型糖尿病（NIDDM）患者与非糖尿病受试者相比，运动能力下降。然而，损伤程度以及与运动能力下降相关的因素尚未完全明确。采用分级跑步机方案对10名久坐不动的无并发症NIDDM患者（年龄51±7岁）和10名年龄及活动量匹配的健康对照者进行了最大运动能力评估。所测量的运动能力的潜在相关因素包括空腹及运动后血糖浓度、空腹胰岛素浓度、糖化血红蛋白A1C、血细胞比容和全血粘度。在最大运动时，糖尿病患者的最大步行时间比对照组低24%，最大摄氧量比对照组低20%（均P<0.05），而两组间的血流动力学指标无差异。在分级运动过程中，在低于最大负荷的工作负荷下，NIDDM患者的摄氧量与工作负荷之间的关系比对照组平均低16%，差异有统计学意义。未发现峰值运动能力与所测量的任何运动能力潜在相关因素之间存在相关性。我们得出结论，NIDDM患者的峰值运动能力受损，且与血糖控制程度无关。NIDDM患者在次最大工作负荷增加期间氧消耗增加率降低，这表明在其他方面健康的糖尿病患者中，氧输送受限可能会损害运动能力。
