Mavroudakis N, Caroyer J M, Brunko E, Zegers de Beyl D
Service de Neurologie, Hôpital Erasme, Brussels, Belgium.
Neurology. 1995 Sep;45(9):1671-7. doi: 10.1212/wnl.45.9.1671.
We evaluated motor responses evoked after magnetic cortical stimulation in dystonia, emphasizing the relationship between resting and facilitation state. We studied 15 normal controls (mean age, 37.9 years; range, 23 to 63) and 13 dystonic patients (mean age, 43.4 years; range, 20 to 56). Surface electrodes were placed over the right first dorsal interosseous muscle to measure motor evoked potentials and inhibitory silent periods obtained with magnetic stimulation. The amplitude ratio of motor evoked potentials measured during facilitation and at rest with low-intensity magnetic stimulation was significantly higher in dystonic patients (15.09) when compared with normal subjects (5.43; p = 0.04). The ratio of duration of silent periods evoked with 120% motor threshold (MT) and MT + 25% magnetic stimulus intensity was significantly higher in dystonic patients (78.4%) when compared with normal subjects (69.7%; p = 0.04). We conclude that with low-intensity magnetic stimulation the relationship between amplitudes of motor potentials evoked at rest and during facilitation, as well as the responses of pathways that mediate silent periods, are disturbed in focal dystonia.
我们评估了肌张力障碍患者在皮层磁刺激后诱发的运动反应，重点关注静息状态与易化状态之间的关系。我们研究了15名正常对照者（平均年龄37.9岁；范围23至63岁）和13名肌张力障碍患者（平均年龄43.4岁；范围20至56岁）。将表面电极置于右侧第一背侧骨间肌上方，以测量磁刺激所获得的运动诱发电位和抑制性静息期。与正常受试者（5.43；p = 0.04）相比，肌张力障碍患者在易化状态下和低强度磁刺激静息时所测得的运动诱发电位的振幅比显著更高（15.09）。与正常受试者（69.7%；p = 0.04）相比，肌张力障碍患者在120%运动阈值（MT）和MT + 25%磁刺激强度下诱发的静息期持续时间的比率显著更高（78.4%）。我们得出结论，在局灶性肌张力障碍中，低强度磁刺激时静息期和易化期诱发的运动电位振幅之间的关系，以及介导静息期的通路的反应均受到干扰。
