Rinne J O, Hublin C, Partinen M, Ruottinen H, Ruotsalainen U, Någren K, Lehikoinen P, Laihinen A
Department of Neurology, University of Turku, Finland.
Neurology. 1995 Sep;45(9):1735-8. doi: 10.1212/wnl.45.9.1735.
We investigated dopamine D2 receptors in the caudate nucleus and putamen with positron emission tomography in seven patients with narcolepsy and seven healthy controls by using [11C]raclopride as a ligand. We applied an equilibrium method and Scatchard principle to give a quantitative estimation of the number (Bmax) and dissociation constant (Kd) of the receptors. Both the Bmax and Kd were within the normal range in the caudate nucleus and putamen in narcoleptic patients. We found no evidence for increased D2 receptor binding in narcolepsy.
我们使用[11C]雷氯必利作为配体，通过正电子发射断层扫描术，对7名发作性睡病患者和7名健康对照者的尾状核和壳核中的多巴胺D2受体进行了研究。我们应用平衡法和斯卡查德原理对受体的数量（Bmax）和解离常数（Kd）进行定量估计。发作性睡病患者尾状核和壳核中的Bmax和Kd均在正常范围内。我们没有发现发作性睡病中D2受体结合增加的证据。
