Skannal D G, Dungy-Poythress L J, Miodovnik M, First M R
Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Ohio, USA.
Obstet Gynecol. 1995 Oct;86(4 Pt 2):641-3. doi: 10.1016/0029-7844(95)00216-e.
Little is known about pregnancy outcomes in multiple organ transplant recipients. We present a case of pregnancy in a patient after liver and kidney transplantation for the genetic disorder of type 1 primary hyperoxaluria.
A 14-year-old Hispanic teenager presented with end-stage renal disease and had a kidney biopsy that revealed hyperoxaluria. A liver biopsy revealed type 1 primary hyperoxaluria. After a year of dialysis and worsening renal status, she underwent a combined orthotopic liver and kidney transplant. The patient subsequently became pregnant, but she required no antihypertensive therapy throughout the prenatal or postpartum period and showed no signs of renal or liver graft rejection. She delivered by cesarean at 38 weeks.
Combined liver and kidney transplant recipients who become pregnant can have a successful outcome.
关于多器官移植受者的妊娠结局，人们了解甚少。我们报告一例因1型原发性高草酸尿症这一遗传性疾病接受肝肾移植的患者妊娠的病例。
一名14岁的西班牙裔青少年因终末期肾病就诊，肾脏活检显示高草酸尿症。肝脏活检显示为1型原发性高草酸尿症。经过一年的透析且肾脏状况恶化后，她接受了原位肝肾联合移植。该患者随后怀孕，但在整个产前和产后期间均无需抗高血压治疗，也未出现肾或肝移植排斥的迹象。她在38周时行剖宫产分娩。
怀孕的肝肾联合移植受者可以有成功的妊娠结局。
