Pruvot F R, Noel C, Declerck N, Valat-Rigot A S, Roumilhac D, Hazzan M, Puech F, Lelièvre G
Unite de Transplantation, Hopital Calmette, CHU, Lille, France.
Transplantation. 1997 Feb 27;63(4):615-6. doi: 10.1097/00007890-199702270-00024.
Pregnancy is now a common, but high-risk event, in young women who have received transplants. Consequences to the fetus are known, but pregnancy may also interfere with graft function. We report the outcome of two successive and successful pregnancies in a 29-year-old woman with type 1 hyperoxaluria, who received a combined liver and kidney transplant. Two healthy children were born at 35 and 37 weeks of gestation, with low birth weight. Liver function remained normal before, during, and after pregnancies up to 52 months after transplantation. Renal function was impaired before the first conception, worsened during both pregnancies, and returned to the previous level in both immediate postpartum periods. However, renal function has declined 17 months after the last delivery. This report shows the feasibility of successive pregnancies in multiple organ transplant recipients, but raises the question of long-term maternal kidney graft survival.
对于接受过移植手术的年轻女性而言，怀孕如今虽是常见之事，但却是高风险事件。胎儿所面临的后果已为人所知，然而怀孕也可能会干扰移植器官的功能。我们报告了一名患有1型高草酸尿症的29岁女性，在接受肝肾联合移植后连续两次成功怀孕的结果。该女性在妊娠35周和37周时分别诞下两个健康婴儿，出生体重较低。在移植后长达52个月的时间里，肝功能在怀孕前、怀孕期间及产后均保持正常。肾功能在首次受孕前受损，在两次怀孕期间均恶化，且在产后即刻均恢复至先前水平。不过，在最后一次分娩17个月后肾功能出现了下降。本报告表明多器官移植受者连续怀孕是可行的，但也引发了关于母体肾脏移植长期存活的问题。
