[利用123I-碘苯并呋喃进行多巴胺-D2受体闪烁扫描术在恶性黑色素瘤中的应用]
[Dopamine-D2 receptor scintigraphy with 123I-iodobenzofuran in malignant melanoma].
作者信息
Steinert H, Huch-Böni R A, Böni R, Westera G, Buck A
机构信息
Departement für Medizinische Radiologie, Universitätsspital Zürich, Schweiz.
出版信息
Nuklearmedizin. 1995 Aug;34(4):146-50.
In recent publications dopamine-D2 receptor scintigraphy with benzamides was postulated for specific imaging of melanoma. In a prospective study the value of 123I-iodobenzofuran (IBF), a highly specific and affine dopamine-D2 receptor ligand was evaluated for the detection of melanoma metastases. With IBF-D2 receptor scintigraphy only 2 of 17 melanoma metastases could be detected. The interpretation of the abdomen was impaired by the hepatobiliary and renal excretion of the radionuclide. The ratio striatum/frontal cortex of 2.75 +/- 0.49 3 h p.i. demonstrated a high D2-receptor binding of the ligand. IBF-D2-receptor scintigraphy is not suitable as a method of staging melanoma.
在最近的出版物中，有人提出用苯甲酰胺进行多巴胺-D2受体闪烁扫描术来对黑色素瘤进行特异性成像。在一项前瞻性研究中，评估了一种高度特异性且亲和力强的多巴胺-D2受体配体——123I-碘苯并呋喃（IBF）用于检测黑色素瘤转移灶的价值。使用IBF-D2受体闪烁扫描术仅能检测出17个黑色素瘤转移灶中的2个。放射性核素的肝胆和肾脏排泄影响了腹部的图像解读。注射后3小时纹状体/额叶皮质的比值为2.75±0.49，表明该配体具有较高的D2受体结合力。IBF-D2受体闪烁扫描术不适用于黑色素瘤的分期。
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