Zdrojewicz Z, Januszewski A, Kwiatkowska D
Katedra i Klinika Endokrynologii, Akademii Medycznej we Wrocławiu.
Postepy Hig Med Dosw. 1994;48(6):689-700.
Paper present a recent review on the formation and clinical significance of advanced glycosylation end products, produced in nonenzymatically glycosylation, called Maillard reaction. The special attention was paid to AGEs role in diabetic and aging processes. Instant of occurring of AGEs in circulation or increase of AGE receptor concentration are many years faster than clinical pathology of vessels, nervous or kidneys connect with diabetes or aging. May be in the future it will be possible to decrease the consequence of Maillard reaction by using pharmacology drugs.
本文介绍了最近一篇关于非酶糖基化产生的晚期糖基化终产物（称为美拉德反应）的形成及其临床意义的综述。特别关注了晚期糖基化终产物在糖尿病和衰老过程中的作用。晚期糖基化终产物在循环中出现或其受体浓度增加的时间比与糖尿病或衰老相关的血管、神经或肾脏的临床病理变化要早很多年。未来或许有可能通过使用药物来减轻美拉德反应的后果。
