Freire-Garabal M, Nů nez-Iglesias M J, Balboa J L, Fernåndez-Rial J C, Rey-Mendez M
NIMUS, Department of Pharmacology, School of Pharmacy, University of Santiago de Compostela, Spain.
Pharmacol Biochem Behav. 1995 Aug;51(4):821-5. doi: 10.1016/0091-3057(95)00040-4.
Several experiments were conducted to evaluate the effects of buspirone, a selective 5-hydroxytryptamine-1A (5-HT1A) anxiolytic, on the immune system of mice exposed to a chronic auditory stressor. Daily injection with 0.5 and 1 mg/kg (intraperitoneally) of buspirone resulted in a dose-dependent reduction in the stress-induced suppression of the natural killer (NK) cell activity and the in vitro and in vivo activity of phagocytosis. Higher doses of buspirone (2.0 mg/kg) showed less robust immunoenhancing effects in stressed mice, and caused a significant suppression of these immune parameters in unstressed mice.
进行了多项实验，以评估选择性5-羟色胺-1A（5-HT1A）抗焦虑药丁螺环酮对暴露于慢性听觉应激源的小鼠免疫系统的影响。每天腹腔注射0.5毫克/千克和1毫克/千克的丁螺环酮，可使应激诱导的自然杀伤（NK）细胞活性抑制以及体外和体内吞噬活性呈剂量依赖性降低。更高剂量的丁螺环酮（2.0毫克/千克）对应激小鼠的免疫增强作用较弱，并对未应激小鼠的这些免疫参数产生显著抑制作用。
