Carey R J, Dai H, Krost M, Huston J P
SUNY Health Science Center, Syracuse, USA.
Pharmacol Biochem Behav. 1995 Aug;51(4):901-8. doi: 10.1016/0091-3057(95)00074-7.
Antagonism of the NMDA receptor with MK-801 is considered to be an effective pharmacologic manipulation to prevent the development of sensitization effects to drugs such as cocaine. The present study investigated this issue by comparing the behavioral response of separate groups of rats to three treatment cycles of either saline, 0.1 mg/kg MK-801, 10 mg/kg cocaine, or combined MK-801-cocaine (0.1/10 mg/kg). The treatments were spaced 1 week apart and were preceded by two nondrug baseline tests. In the first test cycle, the four groups had equivalent activity levels in the two nondrug tests. In the first drug test only the MK-801-cocaine group exhibited hyperactivity. By the third drug test, the MK-801-cocaine group exhibited an enhanced hyperactivity and the MK-801 group became hyperactive. Thus, behavioral drug sensitization developed but only with groups treated with MK-801. Antagonism of the NMDA receptor under some circumstances can be a highly effective treatment for the induction of behavioral sensitization effects.
用MK-801拮抗N-甲基-D-天冬氨酸（NMDA）受体被认为是一种有效的药理学手段，可预防对可卡因等药物产生敏化效应。本研究通过比较不同组大鼠对生理盐水、0.1毫克/千克MK-801、10毫克/千克可卡因或联合使用MK-801-可卡因（0.1/10毫克/千克）三个治疗周期的行为反应来研究这个问题。治疗间隔为1周，在治疗前进行两次非药物基线测试。在第一个测试周期中，四组在两次非药物测试中的活动水平相当。在第一次药物测试中，只有MK-801-可卡因组表现出多动。到第三次药物测试时，MK-801-可卡因组表现出增强的多动，而MK-801组也变得多动。因此，行为性药物敏化出现了，但仅在接受MK-801治疗的组中出现。在某些情况下，拮抗NMDA受体可能是诱导行为敏化效应的一种非常有效的治疗方法。
