Wolf M E, Jeziorski M
Department of Neuroscience, University of Health Sciences/Chicago Medical School, IL 60064.
Brain Res. 1993 Jun 11;613(2):291-4. doi: 10.1016/0006-8993(93)90913-8.
Although coadministration of N-methyl-D-aspartate (NMDA) antagonists has been reported to prevent behavioral sensitization to psychomotor stimulants, it has been suggested that this effect is transitory and that sensitization is unmasked after longer periods of drug abstinence. To test this, rats were coadministered either amphetamine, cocaine, or morphine with the NMDA antagonist MK-801 and tested for sensitization after 7-10 days of abstinence. No sensitization was observed, suggesting that NMDA antagonists do not transiently mask sensitization but instead interfere with long-term processes responsible for its development.
虽然有报道称，N-甲基-D-天冬氨酸（NMDA）拮抗剂的共同给药可预防对精神运动兴奋剂的行为致敏，但有人认为这种作用是暂时的，并且在更长时间的药物戒断后致敏会再次出现。为了验证这一点，给大鼠同时注射苯丙胺、可卡因或吗啡与NMDA拮抗剂MK-801，并在戒断7-10天后测试致敏情况。未观察到致敏现象，这表明NMDA拮抗剂不会暂时掩盖致敏，而是干扰了导致其发展的长期过程。
