抗肿瘤2,6-哌嗪二酮的研究：2,3-二乙酰氧基-4-甲氧羰基-(3',5'-二氧代-N4'取代哌嗪基甲基)苯的合成
Studies on the antitumor 2,6-piperazinediones: synthesis of 2,3-diacetoxy-4-carbomethoxy-(3',5'-dioxo-N4' substituted piperazinyl methyl) benzene.
作者信息
Li Q, Shao H W, Jiang H L, Xie Y Y
机构信息
Department of Synthetic Chemistry, Shanghai Institute of Materia Medica, Academia Sinica, P.R. of China.
出版信息
Pharmazie. 1995 Jul;50(7):447-9.
PMID:7675884
Abstract
The title compounds having the structure of 2,3-diacetoxy-4-carbomethoxy-(3',5'-dioxo-N4'-substituted piperazinyl methyl) benzene were synthesized from 2-hydroxy-3-methoxybenzaldehyde in eight steps. Compound 9h showed a potent inhibitory effect against P388 leukemia cells in vitro.
摘要
具有2,3 - 二乙酰氧基 - 4 - 甲氧基羰基 -（3',5'-二氧代 - N4'-取代哌嗪基甲基）苯结构的标题化合物由2 - 羟基 - 3 - 甲氧基苯甲醛经八步合成。化合物9h在体外对P388白血病细胞显示出强效抑制作用。
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