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通过电子自旋共振自旋探针法检测局部麻醉药和β受体阻滞剂庚卡因对磷脂酰胆碱双层流动性的双相效应。

Biphasic effect of local anesthetic and beta-blocker heptacaine on fluidity of phosphatidylcholine bilayers as detected by ESR spin probe method.

作者信息

Gallová J, Cizmárik J, Balgavý P

机构信息

Department of Physical Chemistry, Faculty of Pharmacy, Comenius University, Bratislava, Slovakia.

出版信息

Pharmazie. 1995 Jul;50(7):486-8.

PMID:7675892
Abstract

Heptacaine (1), the monohydrochloride of [2-(heptyl-oxy)phenyl]-2-(1-piperidinyl)ethyl ester of carbamic acid, exerts a biphasic effect on the fluidity of egg yolk phosphatidylcholine (EYPC) model membranes as detected by the methyl esters of stearic acid spin probes with the paramagnetic doxyl group bound to the C-12 or C-16. The fluidity initially increases with an increase in the molar ratio of 1:EYPC, but a molar ratios above 1:EYPC = 0.5 a decrease of fluidity has been observed.

摘要

庚卡因（1），即氨基甲酸[2 - （庚氧基）苯基]-2 - （1 - 哌啶基）乙酯的盐酸盐，通过与结合在C - 12或C - 16上的顺磁性二氧基团的硬脂酸自旋探针检测，对蛋黄磷脂酰胆碱（EYPC）模型膜的流动性产生双相作用。随着1:EYPC摩尔比的增加，流动性最初会增加，但当摩尔比高于1:EYPC = 0.5时，已观察到流动性下降。

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