Als C, Rösler H
Abteilung Nuklearmedizin, Inselspital Bern.
Schweiz Med Wochenschr. 1995 Aug 8;125(31-32):1495-9.
The frequency distribution of immunogenic and non-immunogenic hyperthyroidism (IH, NIH) was evaluated retrospectively in the former endemic goiter area of Berne over a 15-year period (1976, 1982, and 1991). Out of 12,320 patients referred for thyroid examinations, 9.1% were hyperthyroid. NIH still predominates with a constant frequency of 59%; but the ratio between toxic adenomas (TA) and multifocal functional autonomies (MFA) was significantly inversed, from 2.6 over 0.9 to 0.4. The frequency of TA decreased from 41% to 17% and that of MFA increased from 16% to 38%. The arithmetic mean age at diagnosis was constant: 53.9 (IH), 61.5 (TA) and 67.5 years (MFA). The decreasing frequency of TA over the last 15 years is explained by an increased but still insufficient iodine supply.
在15年期间（1976年、1982年和1991年），对伯尔尼以前的地方性甲状腺肿流行地区免疫原性和非免疫原性甲状腺功能亢进症（免疫性甲状腺功能亢进症、非免疫性甲状腺功能亢进症）的频率分布进行了回顾性评估。在12320例接受甲状腺检查的患者中，9.1%为甲状腺功能亢进症患者。非免疫性甲状腺功能亢进症仍占主导，频率稳定在59%；但毒性腺瘤（TA）与多灶性功能性自主性（MFA）之间的比例显著反转，从2.6比0.9变为0.4。毒性腺瘤的频率从41%降至17%，多灶性功能性自主性的频率从16%增至38%。诊断时的算术平均年龄保持不变：免疫性甲状腺功能亢进症为53.9岁，毒性腺瘤为61.5岁，多灶性功能性自主性为67.5岁。过去15年中毒性腺瘤频率的下降是由于碘供应增加但仍不足所致。
