Als C, Listewnik M, Rösler H, Bartkowiak E
Department of Nuclear Medicine, University of Berne, Inselspital, Switzerland.
Nuklearmedizin. 1995 Jun;34(3):92-9.
Annual occurrences of immunogenic (IH) and non-immunogenic hyperthyroidism (NIH) between Berne (1976, 1982, 1991) and Szczecin (1973, 1980, 1991) were compared. Out of 21,025 patients referred for thyroid examinations, 10.1% (average) were hyperthyroid. In Berne (former endemic goiter region) and Szczecin (without goiter endemicity) IH occurred in 41% and 68%, NIH in 59% and 32% of hyperthyroid patients, respectively. Within a stable incidence of NIH in Berne, toxic adenomas (TA) decreased from 41% (1976) to 17% (1991) (p < 0.005). In Szczecin, where iodine deficiency is in an early stage, the TA frequency did not change significantly: from 24% (1973) to 28% (1991). Increases of TA or of multifocal functional autonomy apparently "mark" incipient or, respectively, decreasing deficiencies in nutritious iodine. Hyperthyroid patients in Berne compared to Szczecin were older, both with IH (54 versus 45 y) and NIH (65 versus 52 y). Age at diagnosis was stable in Berne but increasing (p < 0.05) in Szczecin (from 43 to 52 y).
比较了伯尔尼（1976年、1982年、1991年）和什切青（1973年、1980年、1991年）免疫原性（IH）和非免疫原性甲状腺功能亢进症（NIH）的年发病率。在21,025名接受甲状腺检查的患者中，10.1%（平均）患有甲状腺功能亢进症。在伯尔尼（以前的地方性甲状腺肿地区）和什切青（无甲状腺肿流行情况），分别有41%和68%的甲状腺功能亢进症患者发生IH，59%和32%的患者发生NIH。在伯尔尼，NIH发病率稳定，毒性腺瘤（TA）从41%（1976年）降至17%（1991年）（p<0.005）。在碘缺乏处于早期阶段的什切青，TA频率没有显著变化：从24%（1973年）到28%（1991年）。TA或多灶性功能自主性的增加显然分别“标志着”营养碘的初期缺乏或缺乏程度的降低。与什切青相比，伯尔尼的甲状腺功能亢进症患者年龄更大，无论是IH患者（54岁对45岁）还是NIH患者（65岁对52岁）。伯尔尼的诊断年龄稳定，但什切青的诊断年龄在增加（p<0.05）（从43岁到52岁）。
