Nasibullin B A
Tsitol Genet. 1995 May-Jun;29(3):3-6.
Ninety six outbred males of albino rats of 10-14 months of age were subjected to modeling experimental cerebro-vascular deficiency and were exposed to low frequency vibration and hypokinesia. Ultrastructural changes in neurons and synapses of sensomotor cortex were studied using electron microscopy. It was found that exposure to all harmful factors led to similar ultrastructural changes in soma of neurons and may be considered as hypoxic changes. Lesions in synaptic system depends on the type of the influence. Thus, permanent cerebro-vascular deficiency resulted in increase in light synapses number. Low frequency vibration was accompanied by appearance of synapses with shortened active zone and synapses with great amount of independent vesicles. Hypokinesia was accompanied by appearance of synapses with prolonged active zone and synapse in astrocyte muffs.
选用96只10 - 14月龄的白化远交系雄性大鼠，对其进行实验性脑血管缺损建模，并使其暴露于低频振动和运动不足环境中。采用电子显微镜研究感觉运动皮层神经元和突触的超微结构变化。结果发现，暴露于所有有害因素均导致神经元胞体出现相似的超微结构变化，可视为缺氧变化。突触系统的损伤取决于影响类型。因此，永久性脑血管缺损导致轻度突触数量增加。低频振动伴随着活性区缩短的突触和含有大量独立囊泡的突触出现。运动不足伴随着活性区延长的突触和星形胶质细胞套中的突触出现。
