MacGibbon A L, Brieger G M
Department of Obstetrics and Gynaecology, King George V Memorial Hospital for Mothers and Babies, Sydney, New South Wales.
Aust N Z J Obstet Gynaecol. 1995 May;35(2):217-9. doi: 10.1111/j.1479-828x.1995.tb01878.x.
Cushing syndrome in pregnancy is rare. This is explained by the syndrome's association with amenorrhoea, oligomenorrhoea, infertility and abortions. Cushing syndrome commonly presents with hypertension, weight gain, diabetes, striae or truncal obesity, all of which can be consistent with pregnancy in women without Cushing syndrome. We describe a case of Cushing syndrome in pregnancy secondary to an adrenal cortical tumour which was discovered after an abnormal glucose tolerance test. The woman developed classical features of Cushing syndrome including gestational diabetes and hypertension and was managed successfully to term after a unilateral adrenalectomy at 23 weeks. The case is reported not only because of its rarity but also because the diagnosis was made after a routine screening test for gestational diabetes. Early diagnosis and treatment of adrenal adenoma causing Cushing syndrome in pregnancy reduces maternal and fetal morbidity and mortality.
妊娠期库欣综合征较为罕见。这可由该综合征与闭经、月经过少、不孕及流产的关联来解释。库欣综合征通常表现为高血压、体重增加、糖尿病、皮肤紫纹或躯干肥胖，所有这些在无库欣综合征的妊娠女性中也可能出现。我们描述了一例因肾上腺皮质肿瘤继发的妊娠期库欣综合征病例，该病例在葡萄糖耐量试验异常后被发现。该女性出现了库欣综合征的典型特征，包括妊娠期糖尿病和高血压，并在孕23周时接受单侧肾上腺切除术后成功维持至足月。报告该病例不仅因其罕见，还因为其诊断是在妊娠期糖尿病的常规筛查试验后做出的。早期诊断并治疗妊娠期导致库欣综合征的肾上腺腺瘤可降低母婴发病率和死亡率。
