人心肌中的一氧化氮合酶活性
Nitric oxide synthase activities in human myocardium.
作者信息
de Belder A J, Radomski M W, Why H J, Richardson P J, Bucknall C A, Salas E, Martin J F, Moncada S
机构信息
Department of Cardiology, King's College Hospital, London, UK.
出版信息
Lancet. 1993 Jan 9;341(8837):84-5. doi: 10.1016/0140-6736(93)92559-c.
Myocardial constitutive and inducible nitric oxide (NO) synthase activities were measured in right ventricular tissue from 17 patients with dilated cardiomyopathy (DCM). A significant activity of inducible enzyme was accompanied by a low activity of the constitutive NO synthase. Thus, the myocardium has the capacity to express both NO synthases. NO may have a physiological as well as a pathological role in the human myocardium.
在17例扩张型心肌病（DCM）患者的右心室组织中检测了心肌组成型和诱导型一氧化氮（NO）合酶活性。诱导型酶的活性显著，同时组成型NO合酶的活性较低。因此，心肌具有表达两种NO合酶的能力。NO在人类心肌中可能具有生理和病理作用。
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