Foulkes A G, Harris A
Division of Medical and Molecular Genetics, UMDS, London, England.
Pancreas. 1993 Jan;8(1):3-6. doi: 10.1097/00006676-199301000-00003.
Cystic fibrosis (CF) is a disease that affects the function of specialized epithelial cells within the lungs, gut, pancreas, sweat glands, and male genital ducts. Following the cloning of the CF gene, it is possible to examine tissue-specific expression of this gene. To investigate the onset of the CF disease process, expression of the CF gene in midtrimester human fetal tissues has been analyzed by in situ hybridization using antisense RNA probes. The major site of CF gene expression at this stage of development is in the pancreas. Within the pancreas, CF mRNA is seen to be largely restricted to the epithelium of intralobular and small interlobular ducts.
囊性纤维化（CF）是一种影响肺、肠道、胰腺、汗腺和男性生殖管道内特殊上皮细胞功能的疾病。CF基因克隆后，就有可能检测该基因的组织特异性表达。为了研究CF疾病进程的起始，已使用反义RNA探针通过原位杂交分析了妊娠中期人胎儿组织中CF基因的表达。在这个发育阶段，CF基因表达的主要部位是胰腺。在胰腺内，CF mRNA在很大程度上局限于小叶内和小叶间小导管的上皮。
