Trezise A E, Chambers J A, Wardle C J, Gould S, Harris A
Imperial Cancer Research Fund Laboratories, Institute of Molecular Medicine, Oxford, UK.
Hum Mol Genet. 1993 Mar;2(3):213-8. doi: 10.1093/hmg/2.3.213.
In order to examine the onset of the cystic fibrosis (CF) disease process, the expression of the cystic fibrosis gene (CFTR) has been examined in mid-trimester human foetal tissues by in situ hybridization. CFTR mRNA was detected in the epithelia of pancreatic ducts, small intestine, colon, genital ducts, lung and trachea. The majority of these sites of CFTR expression in the foetus are similar to those seen in adult tissues. However, epithelia of the lung, that contain very little CFTR mRNA in the adult, express high levels of CFTR mRNA in the foetus. Since the lung is the major site of pathology and morbidity in CF these findings have implications for treatment.
为了研究囊性纤维化（CF）疾病进程的起始，通过原位杂交技术检测了妊娠中期人胎儿组织中囊性纤维化基因（CFTR）的表达。在胰腺导管、小肠、结肠、生殖管道、肺和气管的上皮细胞中检测到了CFTR mRNA。胎儿中这些CFTR表达部位大多数与成人组织中所见的相似。然而，在成人中CFTR mRNA含量极少的肺上皮细胞，在胎儿中却表达高水平的CFTR mRNA。由于肺是CF病理和发病的主要部位，这些发现对治疗具有重要意义。
