多巴胺和α-肾上腺素能激动剂对钠钾ATP酶活性的双向调节
Bidirectional regulation of Na+,K(+)-ATPase activity by dopamine and an alpha-adrenergic agonist.
作者信息
Ibarra F, Aperia A, Svensson L B, Eklöf A C, Greengard P
机构信息
Department of Pediatrics, St. Göran's Children's Hospital, Karolinska Institutet, Stockholm, Sweden.
出版信息
Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):21-4. doi: 10.1073/pnas.90.1.21.
Abstract
Catecholamines have pronounced effects on the renal handling of sodium and water, dopamine-promoting sodium and water excretion, and norepinephrine-promoting sodium and water retention. In the present study, using isolated permeabilized renal tubule cells and intact rats, we have shown that these effects can be attributed to opposing actions of these transmitters on renal tubular Na+,K(+)-ATPase activity. The ability of each of these catecholamines to regulate Na+,K(+)-ATPase activity is affected by the concentration of Na+ as well as by the absence or presence of the opposing catecholamine.
摘要
儿茶酚胺对肾脏处理钠和水有显著影响，多巴胺促进钠和水的排泄，而去甲肾上腺素促进钠和水的潴留。在本研究中，我们使用分离的通透肾小管细胞和完整大鼠，表明这些作用可归因于这些递质对肾小管Na⁺,K⁺-ATP酶活性的相反作用。这些儿茶酚胺中每一种调节Na⁺,K⁺-ATP酶活性的能力受Na⁺浓度以及相反儿茶酚胺的存在或缺失的影响。
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