Johnston P G, Kleiner D, Cowan K H
Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20889.
Am J Clin Oncol. 1993 Feb;16(1):34-7.
This report describes a patient with multiply relapsed and advanced metastatic embryonal cell carcinoma who achieved a pathological partial remission (PR) following treatment with a Phase I chemotherapeutic agent, arabinosyl-5-azacytosine (Ara-AC), followed by orchiectomy. The antimetabolic Ara-AC is worthy of further study in patients with germ-cell tumors. It would appear that the antimetabolite Ara-AC may have significant activity in patients with germ-cell tumors.
本报告描述了一名多次复发且伴有晚期转移性胚胎细胞癌的患者，其在接受I期化疗药物阿拉伯糖基-5-氮杂胞苷（Ara-AC）治疗后实现了病理部分缓解（PR），随后进行了睾丸切除术。抗代谢药物Ara-AC在生殖细胞肿瘤患者中值得进一步研究。看来抗代谢药物Ara-AC在生殖细胞肿瘤患者中可能具有显著活性。
